MacDonald has had many successful and well received live performances all over North America. In addition, he has appeared on numerous TV shows including Late Night with David Letterman, The Arsenio Hall Show, Just For Laughs, Showtime's Comedy Club All-Star Show, A&E's An Evening at the Improv, and Comedy Central's The A List. His popularity continues to soar in both the US and Canada. He has hosted both the Gemini Awards and the Just For Laughs 10th Anniversary Special for the CBC. MacDonald also holds the distinction of being the only comedian to perform at each and every Just For Laughs gala show.
MacDonald has starred in three well received specials for the CBC in Canada and for Showtime in the US. His first special, Mike MacDonald; On Target was the very first one hour prime time special by a stand-up comic in the history of the CBC. This success led to MacDonald’s next special, "My House! My Rules!" This special won its prime time slot when it aired in Canada. It also was nominated for two Gemini Awards. The Showtime version of "My House! My Rules!" was nominated for two CableACE Awards, "Best Comedy Special" and "Best Writing in a Comedy Special". His third Showtime special, called “Happy As I Can Be”, was originally slated as a half-hour show. When executives saw the footage, they immediately expanded it to an hour. “Happy As I Can Be” in its one hour format also achieved a number 1 rating when it aired in prime time in Canada on the CBC.